{"hq_id":"hq-c-ino-000092","name":"Beryllium oxide (BeO, beryllia)","context":"human_adult","timestamp":"2026-10-27T20:01:31.853Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000092","sha256":"1882cf74ff522ace331fbfb574e4d58caa44bde4b8fdf0313f2d76f43d1102ee"}]},"risk_level":"extreme","risk_profile":{"magnitude":{"mean":0.863892,"weightedMean":0.863892,"std_dev":0.074315,"confidence_interval_95":[0.775,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.85,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.775,"weight":0.35}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"IARC","year":2012,"value":0.82,"weight":0.41}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"IARC","year":2012,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"IARC","year":2012,"value":1,"weight":0.41}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"IARC","year":2012,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.504567,"disagreement_magnitude":0.353935,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (78th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"src_001","type":"database","title":"PubChem Compound CID 14775","url":"https://pubchem.ncbi.nlm.nih.gov/compound/14775"},{"id":"src_002","type":"epa","title":"EPA CompTox Chemicals Dashboard — DTXSID30872818","url":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID30872818"},{"id":"src_003","type":"reference","title":"ATSDR Toxicological Profile — CAS 1304-56-9","url":"https://www.atsdr.cdc.gov/toxprofiledocs/index.html"},{"id":"r60-2026-09-24-d869-iarc-monographs-available","type":"regulatory","title":"IARC Monographs — Monographs available (index)","year":2026,"url":"https://monographs.iarc.who.int/monographs-available/"},{"id":"r60-2026-09-26-d867-niosh-npg-npgd0054","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Beryllium & beryllium compounds (as Be) (7440-41-7) (reached from the NPG CAS index npgdcas.html, archived 2026-09-25)","url":"https://www.cdc.gov/niosh/npg/npgd0054.html"},{"id":"r60-2026-09-25-d897-eu-cellar-02004L0037-20240408","type":"regulatory","title":"Consolidated TEXT: 32004L0037 — EN — 08.04.2024","url":"https://publications.europa.eu/resource/celex/02004L0037-20240408"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":40,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["exposure_dermal","exposure_ingestion","exposure_inhalation","exposure_ocular","human_adult","human_pregnant","human_teen","human_elderly","human_infant","occupational_exposure"]}