{"hq_id":"hq-c-ino-000089","name":"Chrysotile fiber (hydrated magnesium silicate)","context":"human_adult","timestamp":"2026-10-27T21:00:08.460Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000089","sha256":"af83d758bc36dcfb1e4131eed69c69cd2d8904ad0fc35ef6e5a0241619507f7d"}]},"risk_level":"extreme","risk_profile":{"magnitude":{"mean":0.853698,"weightedMean":0.853698,"std_dev":0.06843,"confidence_interval_95":[0.775,0.95],"source_positions":[{"source":"EPA CTX / IARC","year":2021,"value":0.95,"weight":0.30176},{"source":"NTP","year":2016,"value":0.85,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.775,"weight":0.35}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176},{"source":"NTP","year":2016,"value":0.82,"weight":0.41}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176},{"source":"NTP","year":2016,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176},{"source":"NTP","year":2016,"value":1,"weight":0.41}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176},{"source":"NTP","year":2016,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.5438,"disagreement_magnitude":0.360929,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (78th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"src_001","type":"database","title":"PubChem Compound CID 25477","url":"https://pubchem.ncbi.nlm.nih.gov/compound/25477"},{"id":"src_002","type":"epa","title":"EPA CompTox Chemicals Dashboard — DTXSID0030742","url":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID0030742"},{"id":"src_003","type":"reference","title":"ATSDR Toxicological Profile — CAS 12001-29-5","url":"https://www.atsdr.cdc.gov/toxprofiledocs/index.html"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1001","type":"regulatory","title":"§ 1910.1001 Asbestos.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1001"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-09-24-d869-iarc-monographs-available","type":"regulatory","title":"IARC Monographs — Monographs available (index)","year":2026,"url":"https://monographs.iarc.who.int/monographs-available/"},{"id":"r60-2026-09-26-d867-cc3-niosh-npg-npgd0041","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Asbestos (1332-21-4) (reached from the NPG CAS index npgdcas.html, archived 2026-09-25)","url":"https://www.cdc.gov/niosh/npg/npgd0041.html"},{"id":"pubchem-exp-cameo-chemicals-cid-25477","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 25477; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/25477/JSON?heading=Experimental+Properties"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / IARC:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Rotterdam Convention:annex iii listing — chrysotile (prior informed con","unmapped_classification:ECHA:reach annex xvii entry 6 — total ban of all asbest","unmapped_classification:Health Canada:cepa prohibition regulations — chrysotile asbestos","unmapped_classification:US EPA:tsca section 6(a) final risk-management rule — ban","unmapped_classification:AICIS:australia national ban — all asbestos types","unmapped_classification:ILO:convention 162 (asbestos convention) — controls on"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":40,"warnings":["year_inferred:EPA CTX / IARC:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Rotterdam Convention:annex iii listing — chrysotile (prior informed con","unmapped_classification:ECHA:reach annex xvii entry 6 — total ban of all asbest","unmapped_classification:Health Canada:cepa prohibition regulations — chrysotile asbestos","unmapped_classification:US EPA:tsca section 6(a) final risk-management rule — ban","unmapped_classification:AICIS:australia national ban — all asbestos types","unmapped_classification:ILO:convention 162 (asbestos convention) — controls on"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["exposure_inhalation","human_adult","human_pregnant","human_teen","human_elderly"]}