{"hq_id":"hq-c-ino-000085","name":"Chromium(VI) / Hexavalent Chromium","context":"human_adult","timestamp":"2026-08-28T04:04:46.888Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.817735,"weightedMean":0.817735,"std_dev":0.132693,"confidence_interval_95":[0.85,0.95],"source_positions":[{"source":"IARC","year":1990,"value":0.95,"weight":0.41},{"source":"NTP","year":1998,"value":0.85,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.724274,"weightedMean":0.724274,"std_dev":0.146523,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1990,"value":0.82,"weight":0.41},{"source":"NTP","year":1998,"value":0.82,"weight":0.41}]},"recency":{"mean":0.649573,"weightedMean":0.649573,"std_dev":0.228942,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1990,"value":0.5,"weight":0.41},{"source":"NTP","year":1998,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.910256,"weightedMean":0.910256,"std_dev":0.137365,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1990,"value":1,"weight":0.41},{"source":"NTP","year":1998,"value":1,"weight":0.41}]},"specificity":{"mean":0.800855,"weightedMean":0.800855,"std_dev":0.07784,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1990,"value":0.75,"weight":0.41},{"source":"NTP","year":1998,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.11538,"disagreement_magnitude":0.339684,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_ref","type":"regulatory","title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans — Chromium, Nickel and Welding (Volume 49)","year":1990,"url":"https://www.ncbi.nlm.nih.gov/books/NBK519246/"},{"id":"epa_ref","type":"regulatory","title":"US EPA Integrated Risk Information System (IRIS) — Chromium(VI)","year":1998,"url":"https://cfpub.epa.gov/ncea/iris2/chemicallanding.cfm?substance_nmbr=144"},{"id":"ntp_ref","type":"regulatory","title":"National Toxicology Program — Report on Carcinogens: Chromium Hexavalent Compounds","year":1980,"url":"https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/chromiumhexavalentcompounds.pdf"}],"sources_scope":"context","warnings":["unmapped_classification:US EPA:likely carcinogen (inhalation); potential carcinog"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":12,"warnings":["unmapped_classification:US EPA:likely carcinogen (inhalation); potential carcinog"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","human_pregnant","exposure_inhalation","human_teen","human_elderly","human_infant"]}