{"hq_id":"hq-c-ino-000081","name":"Sodium sulfite (E221)","context":"human_adult","timestamp":"2026-10-27T17:12:31.832Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000081","sha256":"c51f43509bd05200713b3361d8fbdfd45f0c7b89e7715ab7157239c906ddd676"}]},"risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"sodium_sulfite_e221_efsa2016","type":"regulatory","title":"Sodium Sulfite E221 CAS 7757-83-7 Na2SO3 Anhydrous 50.4% SO2 Equivalents; EFSA 2016 Group ADI 0.7 mg SO2 Eq/kg/day E220-E228 Class EFSA Journal 2016;14(4):4438; Sulfite Oxidase SUOX Mitochondrial Molybdopterin Cofactor Sulfate Renal Excretion; SUOX Deficiency Rare AR <1:100000 Neonatal Seizures Opisthotonus Neurodegeneration Sulfite Sulfocysteine Accumulation; Sulfite Sensitivity Class-Wide Asthmatic Bronchoconstriction Pharmacological Not IgE; Wine Beer Dried Vegetables Industrial Potato Processing; Pulp Paper Sulfite Pulping Lignin Delignification Largest Industrial Use; Water Treatment Dechlorination Boiler Feedwater; Textile Dye Stripping; Rapid Aerobic Oxidation Sulfate Half-Life <1h Environmental","year":2016},{"id":"src_iarc_loc_d869","type":"iarc","title":"IARC Monographs — List of Classifications: Sulfites, Group 3 (IARC Monographs Volume(s) 54)","url":"https://monographs.iarc.who.int/list-of-classifications/"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_24437","type":"pubchem","title":"PubChem: Toxicity section (CID 24437)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/24437/JSON?heading=Toxicity"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"pubchem-computed-cid-24437","type":"database","title":"PubChem computed properties for CID 24437 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/24437"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-exp-cameo-chemicals-cid-24437","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 24437; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/24437/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid2044260","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID2044260 (Sodium sulfite (E221))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID2044260"},{"id":"pubchem-computed-structure-cid-24437","type":"database","title":"PubChem computed structure descriptors for CID 24437 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/24437"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:IARC:group 3","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":43,"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:IARC:group 3"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}