{"hq_id":"hq-c-ino-000080","name":"Titanium dioxide","context":"human_adult","timestamp":"2026-08-28T04:04:45.900Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.407895,"weightedMean":0.407895,"std_dev":0.099688,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"IARC","year":2010,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2010,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2010,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2010,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2010,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.335413,"disagreement_magnitude":0.319781,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_tio2_vol93_2010","type":"regulatory","title":"IARC Group 2B Titanium Dioxide Vol 93 2010; Lung Overload Rat Bronchioloalveolar Carcinoma Particle Mechanism; EFSA 2021 No Longer Safe Food Additive Genotoxicity Nanoparticle; EU E171 Ban August 2022 Regulation EU 2022/63; France Domestic Ban January 2020 Precautionary; Sunscreen Mineral Physical UV TiO2 Safe Topical Negligible Skin Penetration SCCS; 7 Million Tonnes/Year Global Production White Pigment; Sulfate Chloride Process Rutile Anatase; Photocatalytic OH Radical UV Sunlit Water Algae Daphnia Fish; TiO2 Nanoparticle WWTP Sludge Aggregation Soil; IARC Group 2B Inhaled Only Not Oral","year":2010}],"sources_scope":"record","warnings":["limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":39},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}