{"hq_id":"hq-c-ino-000079","name":"Sodium nitrate","context":"human_adult","timestamp":"2026-08-28T02:45:42.498Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.515789,"weightedMean":0.515789,"std_dev":0.199376,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"IARC","year":2010,"value":0.7,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2010,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2010,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2010,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2010,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.355331,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (70th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_nitrate_vol94_2010","type":"regulatory","title":"IARC Group 2A Ingested Nitrate Endogenous Nitrosation Vol 94 2010; Entero-Salivary Nitrate Recycling Salivary Bacteria Nitrate Reductase Nitrite; Vegetable Nitrate vs Processed Meat Nitrate Context Paradox; Beetroot Juice Nitrate-Nitrite-NO Cardiovascular Benefit; Chile Saltpeter Atacama Fertilizer; Concentrated Solar Power Molten Salt 600C Heat Transfer; EU E251 150 mg/kg Cured Meat; Drinking Water 50 mg/L EU WHO; Eutrophication Nitrates Directive 91/676/EC Vulnerable Zones; Blue Baby Syndrome Infant Formula Well Water; EU CLP Ox Sol 3 H272","year":2010,"url":"https://www.ncbi.nlm.nih.gov/books/NBK326535/"},{"id":"efsa_nitrates_food_2017","type":"regulatory","title":"EFSA Re-evaluation of Sodium and Potassium Nitrate (E249-E252) as Food Additives — Acceptable Daily Intake (ADI) framework + EFSA-CONTAM Panel cured-meat-cohort opinion","year":2017,"url":"https://doi.org/10.2903/j.efsa.2017.4787"},{"id":"iarc_red_processed_meat_2018","type":"regulatory","title":"IARC Monographs Volume 114 — Red Meat and Processed Meat (Processed Meat classified Group 1 Carcinogenic to Humans for colorectal cancer; canonical sodium-nitrate + nitrite + N-nitroso-compound endogenous-formation framework)","year":2018,"url":"https://www.ncbi.nlm.nih.gov/books/NBK507971/"},{"id":"atsdr_nitrates_nitrites_supplementary","type":"regulatory","title":"ATSDR Toxicological Profile for Nitrate and Nitrite","year":2017,"url":"https://www.atsdr.cdc.gov/toxprofiles/tp204.pdf"},{"id":"epa_drinking_water_nitrate_mcl","type":"regulatory","title":"US EPA National Primary Drinking Water Regulations — Nitrate (NO3⁻) MCL 10 mg/L as N + 1 mg/L Nitrite as N + acute-methemoglobinemia infant + agricultural-runoff cohort framework","year":2024,"url":"https://www.epa.gov/ground-water-and-drinking-water/national-primary-drinking-water-regulations"}],"sources_scope":"record","warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 14 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 14 positiv","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":38,"warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 14 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 14 positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}