{"hq_id":"hq-c-ino-000078","name":"Vanadyl sulfate","context":"human_adult","timestamp":"2026-10-27T21:05:51.041Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000078","sha256":"66ff8650aa8b5412e69a063cae312bbbb7a3ec2981d262fbdbae04c833156277"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.407895,"weightedMean":0.407895,"std_dev":0.099688,"confidence_interval_95":[0.3,0.5],"source_positions":[{"source":"IARC","year":2020,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2020,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2020,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2020,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2020,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.335413,"disagreement_magnitude":0.319781,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"voso4_regulatory_2020","type":"regulatory","title":"Vanadyl Sulfate VOSO4 Vanadium IV Oxysulfate Supplement Bodybuilding Insulin-Mimetic; PTP Inhibition Tyrosine Phosphorylation IRS-1 Insulin Receptor Signaling; IARC Group 2B Vanadium Pentoxide V2O5 Vol 86 2006 Lung (Not VOSO4); Clinical Trials T2DM Modest HbA1c Reduction Insufficient Evidence; GI Toxicity Nausea Diarrhea Dose-Limiting 30 mg V/day; Green Tongue VO2+ Deposits Benign Cosmetic Sign; WHO PMTDI 1.8 mg/day Dietary 10-30 μg/day vs Supplement 30 mg; No UL Established IOM EFSA; Ti-6Al-4V Aerospace Alloy Vanadium; EU CLP Acute Tox 4 H302 H332; IARC Not Evaluated VOSO4","year":2020},{"id":"echa_vanadyl_sulfate_reach","type":"regulatory","title":"ECHA REACH Registration + CLP Notification — Vanadyl sulfate hydrate (Acute Tox. 3 oral; Acute Tox. 4 inhalation; STOT-RE 2 inhalation; Aquatic Acute 1 + Aquatic Chronic 1; vanadium(IV) chemistry distinction from V(V) framework)","year":2019},{"id":"iarc_v2o5_vol86_2006","type":"regulatory","title":"IARC Monographs Volume 86 (2006) — Vanadium pentoxide (V2O5) Group 2B Possibly Carcinogenic to Humans (lung tumors B6C3F1 mouse + F344 rat inhalation; framework reference for vanadyl sulfate inhalation profile distinction)","year":2006},{"id":"niosh_vanadium_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — Vanadium and compounds (V2O5 dust REL 0.05 mg V/m³ TWA; V2O5 fume REL 0.05 mg V/m³; petroleum-refining + steelmaking + cohort framework)","year":2019},{"id":"oehha_vanadyl_sulfate_supplement_dietary","type":"study","title":"OEHHA + NIH Office of Dietary Supplements Framework — Vanadyl Sulfate (insulin-mimetic claim + bodybuilding-supplement use; absence-of-essentiality + GI-renal-toxicity dose-response framework)","year":2018},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_34007","type":"pubchem","title":"PubChem: Toxicity section (CID 34007)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/34007/JSON?heading=Toxicity"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"pubchem-computed-cid-34007","type":"database","title":"PubChem computed properties for CID 34007 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/34007"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-34007","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 34007; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/34007/JSON?heading=Experimental+Properties"},{"id":"pubchem-computed-structure-cid-34007","type":"database","title":"PubChem computed structure descriptors for CID 34007 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/34007"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":40,"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}