{"hq_id":"hq-c-ino-000077","name":"Molybdenum trioxide","context":"human_adult","timestamp":"2026-08-28T04:05:08.094Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.535816,"weightedMean":0.535816,"std_dev":0.178081,"confidence_interval_95":[0.5,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"IARC","year":2018,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2018,"value":0.82,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2018,"value":0.5,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2018,"value":1,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2018,"value":0.75,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.314261,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_moo3_vol118_2018","type":"regulatory","title":"IARC Group 2B Molybdenum Trioxide Vol 118 2018; NTP Inhalation Bioassay Lung Tumors Rats Mice 10 30 mg/m3; Steel Alloy Ferromolybdenum HDS Catalyst Petroleum Refining; Molybdenum Cofactor Moco Molybdopterin Xanthine Oxidase Sulfite Oxidase Aldehyde Oxidase; Moco Deficiency Neonatal Neurological cPMP Therapy; RDA 45 μg/day UL 2000 μg/day Dietary Molybdate Non-Toxic; EU CLP Carc 2 H351 Repr 2 H361d STOT RE 1 H372 Kidneys; Gout Allopurinol Febuxostat Xanthine Oxidoreductase; OSHA PEL 5 mg/m3 Respirable","year":2018},{"id":"ntp_tr_462_moo3","type":"study","title":"NTP Technical Report TR-462 — Toxicology and Carcinogenesis Studies of Molybdenum Trioxide (MoO3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies); canonical IARC-118-driving lung-tumor cohort","year":1997},{"id":"echa_moo3_reach","type":"regulatory","title":"ECHA REACH Registration + CLP Notification — Molybdenum Trioxide (Carc. 1B Group 2B reflection; Acute Tox. 4 oral; Eye Irrit. 2; STOT-RE inhalation framework)","year":2020},{"id":"cal_osha_moo3_pel","type":"regulatory","title":"Cal/OSHA + OSHA 29 CFR 1910.1000 Z-1 + ACGIH TLV — Molybdenum, soluble compounds: 5 mg Mo/m³ TWA + Mo respirable insoluble 10 mg/m³ TWA framework","year":2020},{"id":"niosh_molybdenum_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — Molybdenum (insoluble + soluble compounds; REL 5 mg Mo/m³ TWA; pigment + alloy + catalyst cohort framework)","year":2019}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":37,"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}