{"hq_id":"hq-c-ino-000070","name":"Chromium(III) chloride","context":"human_adult","timestamp":"2026-09-10T09:56:01.376Z","risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.273026,"weightedMean":0.273026,"std_dev":0.024922,"confidence_interval_95":[0.25,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35},{"source":"IARC","year":1990,"value":0.25,"weight":0.41}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1990,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1990,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1990,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1990,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.833853,"disagreement_magnitude":0.307831,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. HQ_DIRECT classifies as higher risk (30th percentile), while IARC concludes lower risk (25th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_criii_vol49_1990","type":"regulatory","title":"IARC Group 3 Chromium III Compounds Vol 49 1990; Chrome Tanning Leather EU Cr(VI) Limit 3 mg/kg REACH Article 65; Chromodulin Insulin Potentiation Essential Trace Element DRI 25-35 μg/day; Cr(III) Poor Membrane Permeability vs Cr(VI) Anion Transporter; Cr(III) Oxidation Cr(VI) Manganese Oxide Soil; EU CLP Repr 2 H361 Suspected Reproductive Toxicant; Chromium Picolinate Supplement EFSA 2010; Leather Tannery Effluent WWTP Cr(OH)3 Precipitation","year":1990}],"sources_scope":"record","warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (single report) (ames: none","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (single report) (ames: none","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":24,"warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (single report) (ames: none","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (single report) (ames: none"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}