{"hq_id":"hq-c-ino-000069","name":"Lead acetate","context":"human_adult","timestamp":"2026-10-27T21:00:42.828Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000069","sha256":"f745b43dcd98538d60fb99407f18efd26d96f1cf60655d120139f0bdbf291157"}]},"risk_level":"severe","risk_profile":{"magnitude":{"mean":0.703698,"weightedMean":0.703698,"std_dev":0.06843,"confidence_interval_95":[0.625,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"IARC","year":2006,"value":0.7,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2006,"value":0.82,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2006,"value":0.5,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2006,"value":1,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2006,"value":0.75,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.5438,"disagreement_magnitude":0.308845,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_pb_vol87_2006","type":"regulatory","title":"IARC Monographs Volume 87: Inorganic and Organic Lead Compounds","year":2006,"url":"http://publications.iarc.fr/105"},{"id":"atsdr_lead_tox_profile","type":"regulatory","title":"ATSDR Toxicological Profile for Lead","year":2020,"url":"https://www.atsdr.cdc.gov/toxprofiles/tp13.pdf"},{"id":"osha_lead_standard_1910_1025","type":"regulatory","title":"OSHA Lead Standard (29 CFR 1910.1025) — PEL 50 µg/m³","year":1978,"url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1025"},{"id":"prop65_lead_acetate","type":"regulatory","title":"California Prop 65 listing — Lead acetate (carcinogen + reproductive toxicant)","year":1987,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"epa_iris_lead","type":"regulatory","title":"US EPA IRIS Assessment: Lead and compounds (inorganic) (CASRN 7439-92-1), carcinogenicity assessment 1988","year":1988,"url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=277"},{"id":"r60-2026-09-29-d899-s3-b05-sccs-opinions-2016-2021","type":"regulatory","title":"SCCS - Opinions 2016 - 2021 - Public Health - European Commission","url":"https://health.ec.europa.eu/scientific-committees/former-scientific-committees/scientific-committee-consumer-safety-2016-2021/sccs-opinions-2016-2021_en"},{"id":"r60-2026-09-29-d899-s3-b05-sccs-opinions-2013-2016","type":"regulatory","title":"SCCS - Opinions 2013 -2016 - Public Health - European Commission","url":"https://health.ec.europa.eu/scientific-committees/former-scientific-committees/scientific-committee-consumer-safety-sccs-2013-2016/sccs-opinions-2013-2016_en"},{"id":"r60-2026-09-29-d899-s3-b05-sccs-opinions-index","type":"regulatory","title":"SCCS - Opinions - Public Health - European Commission","url":"https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en"},{"id":"r60-2026-09-26-d867-cc1-eurlex-cellar-02009R1223-20260518","type":"regulatory","title":"Consolidated TEXT: 32009R1223 — EN — 18.05.2026","url":"https://publications.europa.eu/resource/celex/02009R1223-20260518"},{"id":"r60-2026-09-26-d867-cc3-niosh-npg-nengapdxc","type":"regulatory","title":"Supplementary Exposure Limits | NIOSH | CDC","url":"https://www.cdc.gov/niosh/npg/nengapdxc.html"},{"id":"r60-2026-09-30-d899-s1-b10-niosh-npg-npgd0368-lead","type":"regulatory","title":"CDC - NIOSH Pocket Guide to Chemical Hazards - Lead","url":"https://www.cdc.gov/niosh/npg/npgd0368.html"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-24-d869-iarc-monographs-available","type":"regulatory","title":"IARC Monographs — Monographs available (index)","year":2026,"url":"https://monographs.iarc.who.int/monographs-available/"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_9317","type":"pubchem","title":"PubChem: Toxicity section (CID 9317)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/9317/JSON?heading=Toxicity"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1025","type":"regulatory","title":"29 CFR 1910.1025 Lead — eCFR full-text XML, 2026-09-22","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1025"},{"id":"pubchem-computed-cid-9317","type":"database","title":"PubChem computed properties for CID 9317 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/9317"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-9317","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 9317; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/9317/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-haz-map-information-on-hazardous-chemica-cid-9317","type":"database","title":"Haz-Map, Information on Hazardous Chemicals and Occupational Diseases, as recorded by PubChem (Experimental Properties, CID 9317; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/9317/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid6020773","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID6020773 (Lead acetate)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID6020773"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"pubchem-computed-structure-cid-9317","type":"database","title":"PubChem computed structure descriptors for CID 9317 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/9317"}],"sources_scope":"record","derived_markers":[],"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":47,"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}