{"hq_id":"hq-c-ino-000068","name":"Cadmium chloride","context":"human_adult","timestamp":"2026-10-27T20:02:26.764Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000068","sha256":"b3720dc8a247215be2ca2275853e4e7cc88d4bcb57d142e03f46095448041bba"}]},"risk_level":"severe","risk_profile":{"magnitude":{"mean":0.800329,"weightedMean":0.800329,"std_dev":0.161993,"confidence_interval_95":[0.625,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.339684,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_cd_vol100c_2012","type":"regulatory","title":"CADMIUM AND CADMIUM COMPOUNDS - Arsenic, Metals, Fibres and Dusts - NCBI Bookshelf","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304372/"},{"id":"atsdr_cadmium_tox_profile","type":"regulatory","title":"ATSDR Toxicological Profile for Cadmium","year":2012,"url":"https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=48&tid=15"},{"id":"osha_cadmium_standard_1910_1027","type":"regulatory","title":"OSHA Cadmium Standard (29 CFR 1910.1027) — PEL 5 µg/m³","year":1992,"url":"https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.1027"},{"id":"epa_iris_cadmium","type":"regulatory","title":"US EPA IRIS Assessment: Cadmium (CASRN 7440-43-9), carcinogenicity assessment 1987","year":1987,"url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=141"},{"id":"r60-2026-09-24-d869-iarc-monographs-available","type":"regulatory","title":"IARC Monographs — Monographs available (index)","year":2026,"url":"https://monographs.iarc.who.int/monographs-available/"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_24947","type":"pubchem","title":"PubChem: Toxicity section (CID 24947)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/24947/JSON?heading=Toxicity"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"r60-2026-09-25-d897-niosh-npg-npgd0087","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Cadmium dust (as Cd) (7440-43-9)","url":"https://www.cdc.gov/niosh/npg/npgd0087.html"},{"id":"r60-2026-09-25-d897-eu-cellar-02004L0037-20240408","type":"regulatory","title":"Consolidated TEXT: 32004L0037 — EN — 08.04.2024","url":"https://publications.europa.eu/resource/celex/02004L0037-20240408"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-computed-cid-24947","type":"database","title":"PubChem computed properties for CID 24947 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/24947"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-cameo-chemicals-cid-24947","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 24947; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/24947/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-24947","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 24947; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/24947/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid6020226","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID6020226 (Cadmium chloride)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID6020226"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"pubchem-computed-structure-cid-24947","type":"database","title":"PubChem computed structure descriptors for CID 24947 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/24947"},{"id":"r60-2026-10-18-a5oj-eu-cellar-32008r1272-oj","type":"regulatory","title":"Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006: Annex VI, Part 3, Table 3.1 (Official Journal L 353, 31.12.2008)","year":2008,"url":"https://publications.europa.eu/resource/celex/32008R1272"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":47,"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}