{"hq_id":"hq-c-ino-000068","name":"Cadmium chloride","context":"human_adult","timestamp":"2026-09-10T07:02:54.088Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.800329,"weightedMean":0.800329,"std_dev":0.161993,"confidence_interval_95":[0.625,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.339684,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_cd_vol100c_2012","type":"regulatory","title":"IARC Group 1 Cadmium Compounds Vol 58 1993 Vol 100C 2012; Lung Cancer Kidney Tubular Dysfunction Itai-Itai Osteomalacia Toyama; Metallothionein Cd Renal Accumulation Beta-2-Microglobulin Biomarker; DNA Repair Zinc Finger hMSH2 hMLH1 Inactivation; Metalloestrogen ERα Estrogen Receptor; OSHA 29 CFR 1910.1027 Cadmium Standard Biological Monitoring; EFSA 2009 TWI 2.5 μg/kg bw/week Dietary; EU REACH Restriction Cadmium Plating Pigments PVC Stabilizers; WFD Priority Hazardous Substance EQS 0.08–0.25 μg/L","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304372/"},{"id":"atsdr_cadmium_tox_profile","type":"regulatory","title":"ATSDR Toxicological Profile for Cadmium","year":2012,"url":"https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=48&tid=15"},{"id":"osha_cadmium_standard_1910_1027","type":"regulatory","title":"OSHA Cadmium Standard (29 CFR 1910.1027) — PEL 5 µg/m³","year":1992,"url":"https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.1027"},{"id":"epa_iris_cadmium","type":"regulatory","title":"US EPA IRIS Assessment: Cadmium (CASRN 7440-43-9), carcinogenicity assessment 1987","year":1987,"url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=141"}],"sources_scope":"record","warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 15 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 15 positiv","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":43,"warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 15 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 15 positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}