{"hq_id":"hq-c-ino-000067","name":"Nickel sulfamate","context":"human_adult","timestamp":"2026-10-27T20:01:56.715Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000067","sha256":"0548d04d066d43bac997f9236688005d1cf8c2841b382e699d383a072d654b60"}]},"risk_level":"severe","risk_profile":{"magnitude":{"mean":0.800329,"weightedMean":0.800329,"std_dev":0.161993,"confidence_interval_95":[0.625,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.339684,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_ni_vol100c_2012","type":"regulatory","title":"IARC Monographs Volume 49: Chromium, Nickel and Welding","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304378/"},{"id":"echa_nickel_compounds_svhc","type":"regulatory","title":"ECHA REACH SVHC Candidate List + Annex XIV Authorisation — Nickel Compounds (soluble Ni-salts including Ni-sulfamate; Carc. 1A + Repr. 1B + Resp. Sens. 1 + Skin Sens. 1 group framework)","year":2017,"url":"https://echa.europa.eu/candidate-list-table"},{"id":"niosh_nickel_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — Nickel metal + soluble compounds (REL 0.015 mg Ni/m³ TWA; 'Ca' carcinogen + Sen sensitizer designation; electroplater + refinery + battery-cathode cohort framework)","year":2019,"url":"https://www.cdc.gov/niosh/npg/npgd0445.html"},{"id":"osha_nickel_compounds_pel","type":"regulatory","title":"OSHA 29 CFR 1910.1000 Z-1 — Nickel metal + soluble compounds PEL 1 mg Ni/m³ TWA + Cal/OSHA 0.5 mg Ni/m³ stricter limit + 29 CFR 1926 construction-electroplating framework","year":2020,"url":"https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.1000"},{"id":"grimsrud_nickel_refinery_cohort","type":"study","title":"Grimsrud TK, Berge SR, Haldorsen T, Andersen A — Exposure to different forms of nickel and risk of lung cancer (canonical Kristiansand Falconbridge-refinery cohort framework driving IARC-100C nickel-compounds Group-1 reaffirmation)","year":2002,"url":"https://pubmed.ncbi.nlm.nih.gov/12480657/"},{"id":"r60-2026-09-24-d867-ecfr-40cfr141.62","type":"regulatory","title":"§ 141.62 Maximum contaminant levels for inorganic contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-40.xml?part=141&section=141.62"},{"id":"r60-2026-09-28-d899-s2-b02-ecfr-40cfr413","type":"regulatory","title":"PART 413—ELECTROPLATING POINT SOURCE CATEGORY","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-24/title-40.xml?part=413"},{"id":"r60-2026-09-26-d867-cc4-epa-dwsha-tables-2018","type":"regulatory","title":"2018 Edition of the Drinking Water Standards and Health Advisories Tables (EPA 822-F-18-001)","url":"https://www.epa.gov/system/files/documents/2022-01/dwtable2018.pdf"},{"id":"r60-2026-09-24-d869-iarc-monographs-available","type":"regulatory","title":"IARC Monographs — Monographs available (index)","year":2026,"url":"https://monographs.iarc.who.int/monographs-available/"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"r60-2026-09-25-d897-eu-cellar-02004L0037-20240408","type":"regulatory","title":"Consolidated TEXT: 32004L0037 — EN — 08.04.2024","url":"https://publications.europa.eu/resource/celex/02004L0037-20240408"},{"id":"pubchem-computed-cid-83720","type":"database","title":"PubChem computed properties for CID 83720 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/83720"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"pubchem-computed-structure-cid-83720","type":"database","title":"PubChem computed structure descriptors for CID 83720 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/83720"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":42,"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}