{"hq_id":"hq-c-ino-000066","name":"Chromic acid (chromium trioxide)","context":"human_adult","timestamp":"2026-09-10T11:49:27.665Z","risk_level":"extreme","risk_profile":{"magnitude":{"mean":0.913338,"weightedMean":0.913338,"std_dev":0.04128,"confidence_interval_95":[0.85,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.925,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.85,"weight":0.30176}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.7248,"disagreement_magnitude":0.307221,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while EPA CTX / NTP RoC concludes lower risk (85th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_crvi_vol100c_2012","type":"regulatory","title":"IARC Group 1 Chromium VI Compounds Vol 49 1990 Vol 100C 2012; Chromic Acid CrO3 Hard Chrome Electroplating Lung Cancer; Nasal Septum Perforation Chrome Holes; Cr-DNA Adducts ROS Cr(V) Reductive Activation; EU CLP Carc 1A H350i SVHC REACH Authorisation List; OSHA Cr(VI) Standard 5 μg/m3 2006; Hinkley California Erin Brockovich Groundwater; EU WFD Priority Substance; Aquatic Acute 1 H400","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304377/"},{"id":"osha_crvi_standard_1910_1026","type":"regulatory","title":"OSHA Hexavalent Chromium Standard (29 CFR 1910.1026) — PEL 5 µg/m³","year":2006,"url":"https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.1026"},{"id":"atsdr_chromium_tox_profile","type":"regulatory","title":"ATSDR Toxicological Profile for Chromium","year":2012,"url":"https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=62&tid=17"},{"id":"epa_iris_crvi_inhalation","type":"regulatory","title":"EPA IRIS — Hexavalent chromium inhalation unit risk","year":1998,"url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=144"}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 7 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 7 positive"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":41,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 7 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 7 positive"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}