{"hq_id":"hq-c-ino-000063","name":"Beryllium chloride","context":"human_adult","timestamp":"2026-08-28T04:04:46.634Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.814446,"weightedMean":0.814446,"std_dev":0.138872,"confidence_interval_95":[0.85,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.85,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.074187,"disagreement_magnitude":0.339684,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_beryllium_2012","type":"regulatory","title":"IARC Monographs Volume 58 1993 Volume 100C 2012 Beryllium Group 1; Lung Cancer Occupational Workers RR 2-3; HLA-DP Glu69 CBD Susceptibility; Chronic Beryllium Disease CBD Berylliosis Granulomatous; BeLPT Be Lymphocyte Proliferation Test; OSHA 29 CFR 1910.1024 OEL 0.2 ug/m3; NIOSH REL 0.05 ug/m3; NTP Known Human Carcinogen; Nuclear Neutron Reflector Aerospace; BeCu Alloy X-ray Window; EU Carc 1B H350 Acute Tox 2","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304379/"},{"id":"osha_beryllium_rule_2017","type":"regulatory","title":"OSHA Beryllium Standard (29 CFR 1910.1024) — PEL 0.2 µg/m³ TWA","year":2017,"url":"https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.1024"},{"id":"atsdr_beryllium_tox_profile","type":"regulatory","title":"ATSDR Toxicological Profile for Beryllium","year":2023,"url":"https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=1441&tid=33"}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (single report) (ames: none","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (single report) (ames: none"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":39,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (single report) (ames: none","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (single report) (ames: none"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}