{"hq_id":"hq-c-ino-000062","name":"Cobalt chloride","context":"human_adult","timestamp":"2026-08-28T04:16:25.922Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.538816,"weightedMean":0.538816,"std_dev":0.174454,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"IARC","year":2022,"value":0.7,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2022,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2022,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2022,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2022,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.344616,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (70th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_cobalt_2012","type":"regulatory","title":"IARC Monographs Volume 52 1991 Volume 86 2006 Volume 100C 2012 Cobalt Group 2B; Cobalt-WC Hard Metal Group 2A; HIF-1alpha Prolyl Hydroxylase Inhibition Pseudo-Hypoxia; ROS 8-OHdG Oxidative DNA Damage; EU Carc 1B H350i Repr 1B H360F SVHC REACH Authorization; Humidity Indicator Blue Anhydrous Pink Hexahydrate; Hard Metal Lung Disease HMLD Cobalt Lung; LiCoO2 EV Battery Cathode; DRC Artisanal Mining Child Exposure; Aquatic Acute 1 H400","year":2012},{"id":"echa_cobalt_chloride_svhc","type":"regulatory","title":"ECHA REACH SVHC Candidate List — Cobalt(II) Chloride (Carc. 1B + Repr. 1B + Resp. Sens. 1 + Skin Sens. 1; SVHC inclusion 2010; CoCl2 + Co-acetate + Co-sulfate + Co-nitrate group framework)","year":2010},{"id":"niosh_cobalt_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — Cobalt metal, dust, and fume (REL 0.05 mg/m³ TWA; A3 carcinogen + Sen sensitizer designation; hard-metal + battery + pigment cohort framework)","year":2019},{"id":"acgih_cobalt_tlv","type":"regulatory","title":"ACGIH TLV-TWA — Cobalt and inorganic compounds (0.02 mg Co/m³ TWA; A3 + SEN; hard-metal disease + occupational asthma + cardiomyopathy cohort framework)","year":2024},{"id":"lison_hard_metal_cohort_1996","type":"study","title":"Lison D, Lauwerys R, Demedts M, Nemery B — Experimental research into the pathogenesis of cobalt/hard metal lung disease (canonical Belgian-Italian hard-metal-cohort framework + cobalt-tungsten-carbide IARC-Group-2A driver)","year":1996}],"sources_scope":"record","warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: none, 2 positive / 1","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: none, 2 positive / 1","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":39,"warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: none, 2 positive / 1","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: none, 2 positive / 1"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}