{"hq_id":"hq-c-ino-000061","name":"Nickel sulfate","context":"human_adult","timestamp":"2026-06-11T22:32:59.516Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.814446,"weightedMean":0.814446,"std_dev":0.138872,"confidence_interval_95":[0.85,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.85,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.074187,"disagreement_magnitude":0.339684,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[],"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:EPA CTX / Health Canada:group i: cepa (carcinogenic to humans)","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 9 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 9 positive"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":40,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:EPA CTX / Health Canada:group i: cepa (carcinogenic to humans)","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 9 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 9 positive"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer"}