{"hq_id":"hq-c-ino-000060","name":"Radium-226","context":"human_adult","timestamp":"2026-10-27T18:07:36.492Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000060","sha256":"aba1a75a6294f12eada4a3f136c61d8e410a61f96e52d5a302066952ea4c7e65"}]},"risk_level":"severe","risk_profile":{"magnitude":{"mean":0.782692,"weightedMean":0.782692,"std_dev":0.13275,"confidence_interval_95":[0.625,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"US EPA","year":2000,"value":0.75,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.724274,"weightedMean":0.724274,"std_dev":0.146523,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41},{"source":"US EPA","year":2000,"value":0.82,"weight":0.41}]},"recency":{"mean":0.649573,"weightedMean":0.649573,"std_dev":0.228942,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41},{"source":"US EPA","year":2000,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.910256,"weightedMean":0.910256,"std_dev":0.137365,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41},{"source":"US EPA","year":2000,"value":1,"weight":0.41}]},"specificity":{"mean":0.800855,"weightedMean":0.800855,"std_dev":0.07784,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41},{"source":"US EPA","year":2000,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.115,"disagreement_magnitude":0.339684,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_radium_v78_2001","type":"regulatory","title":"IARC Monographs Vol 100D: Radiation — Radium-224/-226/-228 and their decay products, Group 1 (carcinogenic to humans; reaffirms orig. Vol 78, 2001); Radium-Girls dial-painter osteosarcoma/leukemia","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304363/"},{"id":"epa_radionuclides_rule_2000","type":"regulatory","title":"US EPA Radionuclides Rule 2000: Combined Ra-226+Ra-228 MCL 5 pCi/L MCLG 0; Group A Known Carcinogen; Lifetime Cancer Risk 1–2×10−4 at MCL; Ion Exchange Reverse Osmosis Lime Softening Treatment; Midwest Southeast Aquifer Occurrence","year":2000,"url":"https://www.epa.gov/dwreginfo/radionuclides-rule"},{"id":"epa_radionuclides_group_a","type":"regulatory","title":"US EPA: Tools for Calculating Radiation Dose and Risk - all radionuclides classified as Group A carcinogens","year":2026,"url":"https://www.epa.gov/radiation/tools-calculating-radiation-dose-and-risk"},{"id":"r60-2026-09-26-d867-cc2-ecfr-40cfr141.66","type":"regulatory","title":"§ 141.66 Maximum contaminant levels for radionuclides.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-24/title-40.xml?part=141&section=141.66"},{"id":"r60-2026-09-28-d899-s2-b02-fr-2000-12-07-00-30421-radionuclides-final-rule","type":"regulatory","title":"Federal Register :: National Primary Drinking Water Regulations; Radionuclides; Final Rule","url":"https://www.federalregister.gov/documents/2000/12/07/00-30421/national-primary-drinking-water-regulations-radionuclides-final-rule"},{"id":"r60-2026-09-26-d867-cc4-epa-dwsha-tables-2018","type":"regulatory","title":"2018 Edition of the Drinking Water Standards and Health Advisories Tables (EPA 822-F-18-001)","url":"https://www.epa.gov/system/files/documents/2022-01/dwtable2018.pdf"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-computed-cid-9877911","type":"database","title":"PubChem computed properties for CID 9877911 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/9877911"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-9877911","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 9877911; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/9877911/JSON?heading=Experimental+Properties"},{"id":"pubchem-computed-structure-cid-9877911","type":"database","title":"PubChem computed structure descriptors for CID 9877911 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/9877911"}],"sources_scope":"record","derived_markers":[],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":37},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","human_pregnant","human_teen","human_elderly","human_infant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}