{"hq_id":"hq-c-ino-000059","name":"Fluorosilicic acid","context":"human_adult","timestamp":"2026-10-27T18:07:41.498Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000059","sha256":"b60ad314b4cdef0e8e20dd9a3220a797937167f4104d4a8e3e9f8a4e4fe8d4e7"}]},"risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"epa_fluoride_mcl_2015","type":"regulatory","title":"US EPA Fluoride MCL 4 mg/L SMCL 2 mg/L; Fluorosilicic Acid 77% US Water Fluoridation; Phosphate Fertilizer Manufacturing Byproduct; Hydrolysis to Fluoride Ion Complete at Dilution; No Separate Carcinogenicity Classification; 0.7 mg/L Optimal CDC Recommendation","year":2015},{"id":"cdc_water_fluoridation_manual_2020","type":"regulatory","title":"CDC Community Water Fluoridation Operational Manual 2020: 10 Great Public Health Achievements; Dental Caries Prevention; 0.7 mg/L Optimal Level 2015 Update from 0.7–1.2; Infant Formula Reconstitution Guidance; Fluorosilicic Acid Chemistry and Handling","year":2020},{"id":"r60-2026-09-24-d867-ecfr-40cfr141.62","type":"regulatory","title":"§ 141.62 Maximum contaminant levels for inorganic contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-40.xml?part=141&section=141.62"},{"id":"r60-2026-09-24-d867-ecfr-40cfr143.3","type":"regulatory","title":"§ 143.3 Secondary maximum contaminant levels.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-40.xml?part=143&section=143.3"},{"id":"r60-2026-09-28-d899-s2-b02-epa-npdwr-table","type":"regulatory","title":"National Primary Drinking Water Regulations | US EPA","url":"https://www.epa.gov/ground-water-and-drinking-water/national-primary-drinking-water-regulations"},{"id":"r60-2026-09-28-d899-s2-b03-epa-secondary-standards-nuisance-chemicals","type":"regulatory","title":"Secondary Drinking Water Standards: Guidance for Nuisance Chemicals | US EPA","url":"https://www.epa.gov/sdwa/secondary-drinking-water-standards-guidance-nuisance-chemicals"},{"id":"r60-2026-09-28-d899-s2-b02-epa-nrwqc-aquatic-life-criteria-table","type":"regulatory","title":"National Recommended Water Quality Criteria - Aquatic Life Criteria Table | US EPA","url":"https://www.epa.gov/wqc/national-recommended-water-quality-criteria-aquatic-life-criteria-table"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_21863527","type":"pubchem","title":"PubChem: Toxicity section (CID 21863527)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/21863527/JSON?heading=Toxicity"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-computed-cid-21863527","type":"database","title":"PubChem computed properties for CID 21863527 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/21863527"},{"id":"pubchem-exp-cameo-chemicals-cid-21863527","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 21863527; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/21863527/JSON?heading=Experimental+Properties"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"pubchem-computed-structure-cid-21863527","type":"database","title":"PubChem computed structure descriptors for CID 21863527 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/21863527"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:US EPA (SDWA/NPDWR):no carcinogenicity classification; regulated as a ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":39,"warnings":["unmapped_classification:US EPA (SDWA/NPDWR):no carcinogenicity classification; regulated as a ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}