{"hq_id":"hq-c-ino-000048","name":"Copper nanoparticles (nano-Cu)","context":"human_adult","timestamp":"2026-10-27T18:57:38.969Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000048","sha256":"5e94b439e12c319c01386b4ddce8eb6919122a2ce9afe00e5cf2a6227e2682c7"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"scenihr_nano_2015","type":"regulatory","title":"EU Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR): Final Opinion on the Safety of Nanomaterials in Food — Nano-CeO2 as diesel fuel additive (Eolys); biopersistent lung particle; NTP 2-year inhalation bioassay lung tumors at high dose; redox-active antioxidant/pro-oxidant dual behavior (2015)","year":2015},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"29 CFR 1910.1000 Air contaminants (Tables Z-1, Z-2, Z-3) — eCFR full-text XML, 2026-09-22","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"src_pubchem_tox_23978","type":"pubchem","title":"PubChem: Toxicity section (CID 23978)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/23978/JSON?heading=Toxicity"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"ctx_pred_dtxsid2023985","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID2023985 (Copper nanoparticles (nano-Cu))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID2023985"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:NIOSH:occupational exposure limit","unmapped_classification:OSHA:occupational exposure limit","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1a (score: high)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":54,"warnings":["unmapped_classification:NIOSH:occupational exposure limit","unmapped_classification:OSHA:occupational exposure limit","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1a (score: high)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_inhalation","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant"]}