{"hq_id":"hq-c-ino-000044","name":"Nickel (elemental)","context":"human_adult","timestamp":"2026-10-27T21:00:18.183Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000044","sha256":"4a23197a476c9c9b01b57d4571fc3225c77b9f7774c0da4efe9215bd7ed85f6b"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.552412,"weightedMean":0.552412,"std_dev":0.188282,"confidence_interval_95":[0.3,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.5,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.730777,"weightedMean":0.730777,"std_dev":0.143494,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.544216,"weightedMean":0.544216,"std_dev":0.283401,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.916353,"weightedMean":0.916353,"std_dev":0.134526,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.7974,"weightedMean":0.7974,"std_dev":0.076231,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.385545,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_chromium_v100c_2012","type":"regulatory","title":"IARC Monographs Volume 100C: Arsenic, Metals, Fibres and Dusts — Chromium (VI) Compounds Group 1 (Lung Cancer, Nasal/Sinus Cancer), Nickel Compounds Group 1, Beryllium Group 1 (2012)","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304377/"},{"id":"epa_ccl5_2022","type":"regulatory","title":"US EPA: Contaminant Candidate List 5 (CCL5) — Final List of Unregulated Contaminants for Regulatory Evaluation under SDWA (2022); includes nickel, cobalt, vanadium, PFAS, and 97 additional chemical and microbial contaminants","year":2022},{"id":"r60-2026-09-26-d867-niosh-npg-npgd0445","type":"regulatory","title":"CDC - NIOSH Pocket Guide to Chemical Hazards - Nickel metal and other compounds (as Ni)","url":"https://www.cdc.gov/niosh/npg/npgd0445.html"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-10-01-dd54-hc-trvs-v2-h128-1-11-638","type":"regulatory","title":"Federal Contaminated Site Risk Assessment in Canada, Part II: Health Canada Toxicological Reference Values (TRVs) and Chemical-Specific Factors, Version 2.0","url":"http://publications.gc.ca/collections/collection_2012/sc-hc/H128-1-11-638-eng.pdf"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) (secondary: unofficial by its own statement)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:NIOSH:occupational exposure limit","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Health Canada:group vi: cepa (unclassifiable with respect to car","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Germany, as recorded by ToxValDB:skin sensitization: sah (score: high)","unmapped_classification:Australia, as recorded by ToxValDB:skin sensitization: skin sensitisation - category ","unmapped_classification:Canada, as recorded by ToxValDB:skin sensitization: skin sensitization - category ","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":43,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:NIOSH:occupational exposure limit","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Health Canada:group vi: cepa (unclassifiable with respect to car","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Germany, as recorded by ToxValDB:skin sensitization: sah (score: high)","unmapped_classification:Australia, as recorded by ToxValDB:skin sensitization: skin sensitisation - category ","unmapped_classification:Canada, as recorded by ToxValDB:skin sensitization: skin sensitization - category ","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_inhalation","human_teen","human_elderly","human_infant","human_pregnant"]}