{"hq_id":"hq-c-ino-000043","name":"Hexavalent chromium (Cr(VI))","context":"human_adult","timestamp":"2026-10-27T21:05:50.347Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000043","sha256":"c6a63786d059183baafea1d1b32b07c0053d4a738f575a0bc32e3e997c48b353"}]},"risk_level":"severe","risk_profile":{"magnitude":{"mean":0.787265,"weightedMean":0.787265,"std_dev":0.122424,"confidence_interval_95":[0.625,0.95],"source_positions":[{"source":"EPA CTX / IARC","year":2021,"value":0.95,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.85,"weight":0.30176},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.730777,"weightedMean":0.730777,"std_dev":0.143494,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.544216,"weightedMean":0.544216,"std_dev":0.283401,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.916353,"weightedMean":0.916353,"std_dev":0.134526,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.7974,"weightedMean":0.7974,"std_dev":0.076231,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.18384,"disagreement_magnitude":0.356749,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_chromium_v100c_2012","type":"regulatory","title":"IARC Monographs Volume 100C: Arsenic, Metals, Fibres and Dusts — Chromium (VI) Compounds Group 1 (Lung Cancer, Nasal/Sinus Cancer), Nickel Compounds Group 1, Beryllium Group 1 (2012)","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304377/"},{"id":"epa_mcl_inorganics","type":"regulatory","title":"US EPA: National Primary Drinking Water Regulations — Inorganic Chemicals (40 CFR 141.62); Total Chromium MCL 100 μg/L, Barium MCL 2 mg/L, Uranium MCL 30 μg/L, Selenium MCL 50 μg/L, Manganese SMCL 50 μg/L","year":1992,"url":"https://www.epa.gov/ground-water-and-drinking-water/national-primary-drinking-water-regulations"},{"id":"epa_crvi_iris","type":"regulatory","title":"US EPA IRIS: Chromium VI — Inhalation Unit Risk (1998 Final; Toxicological Review updated 2024)","year":1998,"url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=144"},{"id":"r60-2026-09-26-d867-niosh-npg-npgd0138","type":"regulatory","title":"CDC - NIOSH Pocket Guide to Chemical Hazards - Chromic acid and chromates","url":"https://www.cdc.gov/niosh/npg/npgd0138.html"},{"id":"r60-2026-09-27-d899-s2-r1-epa-sdwa-regulations-under-development","type":"regulatory","title":"Drinking Water Regulations Under Development or Review | US EPA","url":"https://www.epa.gov/dwstandardsregulations/drinking-water-regulations-under-development-or-review"},{"id":"r60-2026-09-28-d899-s2-b02-epa-chromium-in-drinking-water","type":"regulatory","title":"Chromium in Drinking Water | US EPA","url":"https://www.epa.gov/sdwa/chromium-drinking-water"},{"id":"r60-2026-09-26-d867-cc2-swrcb-hexavalent-chromium","type":"regulatory","title":"Hexavalent Chromium (Chromium-6) | California State Water Resources Control Board","url":"https://www.waterboards.ca.gov/drinking_water/certlic/drinkingwater/Chromium6.html"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-10-01-dd54-hc-trvs-v2-h128-1-11-638","type":"regulatory","title":"Federal Contaminated Site Risk Assessment in Canada, Part II: Health Canada Toxicological Reference Values (TRVs) and Chemical-Specific Factors, Version 2.0","url":"http://publications.gc.ca/collections/collection_2012/sc-hc/H128-1-11-638-eng.pdf"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1026","type":"regulatory","title":"29 CFR 1910.1026 Chromium (VI) — eCFR full-text XML, 2026-09-22","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1026"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"r60-2026-09-25-d897-eu-cellar-02004L0037-20240408","type":"regulatory","title":"Consolidated TEXT: 32004L0037 — EN — 08.04.2024","url":"https://publications.europa.eu/resource/celex/02004L0037-20240408"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Health Canada:group i: cepa (carcinogenic to humans)","unmapped_classification:Germany, as recorded by ToxValDB:skin sensitization: sh (score: high)"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":40,"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Health Canada:group i: cepa (carcinogenic to humans)","unmapped_classification:Germany, as recorded by ToxValDB:skin sensitization: sh (score: high)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_inhalation","human_teen","human_elderly","human_infant","human_pregnant","exposure_ingestion","aquatic_life","exposure_dermal","exposure_ocular","occupational_exposure"]}