{"hq_id":"hq-c-ino-000043","name":"Hexavalent chromium (Cr(VI))","context":"human_adult","timestamp":"2026-08-28T04:13:22.020Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.787265,"weightedMean":0.787265,"std_dev":0.122424,"confidence_interval_95":[0.75,0.95],"source_positions":[{"source":"EPA CTX / IARC","year":2021,"value":0.95,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.85,"weight":0.30176},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.730777,"weightedMean":0.730777,"std_dev":0.143494,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.544216,"weightedMean":0.544216,"std_dev":0.283401,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.916353,"weightedMean":0.916353,"std_dev":0.134526,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.7974,"weightedMean":0.7974,"std_dev":0.076231,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.18384,"disagreement_magnitude":0.356749,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_chromium_v100c_2012","type":"regulatory","title":"IARC Monographs Volume 100C: Arsenic, Metals, Fibres and Dusts — Chromium (VI) Compounds Group 1 (Lung Cancer, Nasal/Sinus Cancer), Nickel Compounds Group 1, Beryllium Group 1 (2012)","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304377/"},{"id":"epa_mcl_inorganics","type":"regulatory","title":"US EPA: National Primary Drinking Water Regulations — Inorganic Chemicals (40 CFR 141.62); Total Chromium MCL 100 μg/L, Barium MCL 2 mg/L, Uranium MCL 30 μg/L, Selenium MCL 50 μg/L, Manganese SMCL 50 μg/L","year":1992,"url":"https://www.epa.gov/ground-water-and-drinking-water/national-primary-drinking-water-regulations"}],"sources_scope":"context","warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / IRIS:carcinogenic potential cannot be determined","unmapped_classification:EPA CTX / Health Canada:group i: cepa (carcinogenic to humans)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: sh (score: high)"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":35,"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / IRIS:carcinogenic potential cannot be determined","unmapped_classification:EPA CTX / Health Canada:group i: cepa (carcinogenic to humans)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: sh (score: high)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_inhalation","human_teen","human_elderly","human_infant","human_pregnant"]}