{"hq_id":"hq-c-ino-000043","name":"Hexavalent chromium (Cr(VI))","context":"human_adult","timestamp":"2026-06-17T13:15:40.562Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.710589,"weightedMean":0.710589,"std_dev":0.234687,"confidence_interval_95":[0.75,0.95],"source_positions":[{"source":"EPA CTX / IARC","year":2021,"value":0.95,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.85,"weight":0.30176},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.730777,"weightedMean":0.730777,"std_dev":0.143494,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.544216,"weightedMean":0.544216,"std_dev":0.283401,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.916353,"weightedMean":0.916353,"std_dev":0.134526,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.7974,"weightedMean":0.7974,"std_dev":0.076231,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.395152,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[],"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / IRIS:carcinogenic potential cannot be determined","unmapped_classification:EPA CTX / IRIS:a (human carcinogen)","unmapped_classification:EPA CTX / Health Canada:group i: cepa (carcinogenic to humans)","unmapped_classification:EPA CTX / EPA OPP:group a human carcinogen by inhalation","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: sh (score: high)"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":35,"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / IRIS:carcinogenic potential cannot be determined","unmapped_classification:EPA CTX / IRIS:a (human carcinogen)","unmapped_classification:EPA CTX / Health Canada:group i: cepa (carcinogenic to humans)","unmapped_classification:EPA CTX / EPA OPP:group a human carcinogen by inhalation","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: sh (score: high)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer"}