{"hq_id":"hq-c-ino-000042","name":"Antimony trioxide (FR synergist)","context":"human_adult","timestamp":"2026-10-27T17:12:11.756Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000042","sha256":"bdfdb5d0e529896cdc33732aba1d813b8484d8ae59785637cd05302b31706c28"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.525039,"weightedMean":0.525039,"std_dev":0.198426,"confidence_interval_95":[0.3,0.7],"source_positions":[{"source":"IARC","year":2023,"value":0.7,"weight":0.45018},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.680031,"weightedMean":0.680031,"std_dev":0.158741,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2023,"value":0.82,"weight":0.45018}]},"recency":{"mean":0.746268,"weightedMean":0.746268,"std_dev":0.223726,"confidence_interval_95":[0.549,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2023,"value":0.549,"weight":0.45018}]},"methodology":{"mean":0.86878,"weightedMean":0.86878,"std_dev":0.14882,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2023,"value":1,"weight":0.45018}]},"specificity":{"mean":0.824358,"weightedMean":0.824358,"std_dev":0.084331,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2023,"value":0.75,"weight":0.45018}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.341965,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (70th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_sb2o3_v47_1989","type":"regulatory","title":"IARC Monographs Volume 47 (1989): Antimony Trioxide — Group 2B (superseded by Volume 131, 2023: trivalent antimony Group 2A); inhalation-route lung tumours in rats, limited human evidence from smelter workers, FR synergist applications","year":1989},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"r60-2026-09-30-d969-niosh-npg-npgd0036-antimony","type":"regulatory","title":"CDC - NIOSH Pocket Guide to Chemical Hazards - Antimony","url":"https://www.cdc.gov/niosh/npg/npgd0036.html"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"}],"sources_scope":"context","derived_markers":[],"warnings":["limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":44},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_inhalation","human_teen","human_elderly","human_infant","human_pregnant"],"unsourced_values":["safety.dose_response.ld50"]}