{"hq_id":"hq-c-ino-000030","name":"Copper","context":"human_adult","timestamp":"2026-10-27T20:02:51.771Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000030","sha256":"d0168ec3d3c1525795a1754b79d7fcf412fc5374b28571fed5fa08afce77c52a"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"atsdr_copper_tox","type":"regulatory","title":"ATSDR: Toxicological Profile for Copper — Essential vs Toxic Threshold, Wilson's Disease, Lead and Copper Rule, Plumbing Leaching, and Dietary Sources","year":2004},{"id":"epa_copper_aquatic","type":"regulatory","title":"US EPA: Aquatic Life Ambient Water Quality Criteria for Copper — Freshwater Criterion (Hardness-Adjusted), Marine Criterion (3.1 μg/L), Salmonid Olfactory Impairment, and Stormwater Runoff Context","year":2007},{"id":"ecfr_40cfr141_80","type":"regulatory","title":"§ 141.80 General requirements and action level.","year":2026,"url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-24/title-40.xml?part=141&section=141.80"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-24-d867-ecfr-40cfr141.62","type":"regulatory","title":"§ 141.62 Maximum contaminant levels for inorganic contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-40.xml?part=141&section=141.62"},{"id":"r60-2026-09-26-d867-cc2-ecfr-40cfr141.51","type":"regulatory","title":"§ 141.51 Maximum contaminant level goals for inorganic contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-24/title-40.xml?part=141&section=141.51"},{"id":"r60-2026-09-28-d899-s2-b02-epa-npdwr-table","type":"regulatory","title":"National Primary Drinking Water Regulations | US EPA","url":"https://www.epa.gov/ground-water-and-drinking-water/national-primary-drinking-water-regulations"},{"id":"r60-2026-09-28-d899-s2-b02-epa-rsl-generic-tables","type":"regulatory","title":"Regional Screening Levels (RSLs) - Generic Tables | US EPA","url":"https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables"},{"id":"r60-2026-09-26-d867-cc4-epa-dwsha-tables-2018","type":"regulatory","title":"2018 Edition of the Drinking Water Standards and Health Advisories Tables (EPA 822-F-18-001)","url":"https://www.epa.gov/system/files/documents/2022-01/dwtable2018.pdf"},{"id":"r60-2026-09-25-d449-iris-368","type":"regulatory","title":"Copper | CASRN 7440-50-8 | DTXSID2023985 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=368"},{"id":"r60-2026-10-01-dd54-hc-trvs-v2-h128-1-11-638","type":"regulatory","title":"Federal Contaminated Site Risk Assessment in Canada, Part II: Health Canada Toxicological Reference Values (TRVs) and Chemical-Specific Factors, Version 2.0","url":"http://publications.gc.ca/collections/collection_2012/sc-hc/H128-1-11-638-eng.pdf"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_23978","type":"pubchem","title":"PubChem: Toxicity section (CID 23978)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/23978/JSON?heading=Toxicity"},{"id":"r60-2026-09-25-d867-niosh-npg-npgd0150","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Copper (dusts and mists, as Cu) (7440-50-8) (reached from the NPG CAS index npgdcas.html, archived 2026-09-25)","url":"https://www.cdc.gov/niosh/npg/npgd0150.html"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"ctx_pred_dtxsid2023985","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID2023985 (Copper)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID2023985"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-23978","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 23978; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/23978/JSON?heading=Experimental+Properties"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / Health Canada:iom, 2001 (\"there is little convincing evidence in","unmapped_classification:EPA IRIS:group d not classifiable as to human carcinogenici","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1a (score: high)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":53,"warnings":["unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / Health Canada:iom, 2001 (\"there is little convincing evidence in","unmapped_classification:EPA IRIS:group d not classifiable as to human carcinogenici","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1a (score: high)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_ingestion","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}