{"hq_id":"hq-c-ino-000019","name":"Sodium hydroxide (lye)","context":"human_adult","timestamp":"2026-10-27T21:06:05.159Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000019","sha256":"9aa1559289f2f05a75beae55275c769ba16c05836ca3c4d54170db8ae4c90712"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.35,"weightedMean":0.35,"std_dev":0,"confidence_interval_95":[0.35,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"epa_sodium_hydroxide_reg","type":"regulatory","title":"US EPA: Sodium Hydroxide — Integrated Risk Information System (IRIS) and Hazardous Substance Fact Sheet","year":2000},{"id":"cpsc_caustics_guidance","type":"regulatory","title":"US CPSC: Caustic Household Products — Poison Prevention Packaging Act Compliance and Consumer Safety Data","year":2018},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) (secondary: unofficial by its own statement)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_14798","type":"pubchem","title":"PubChem: Toxicity section (CID 14798)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/14798/JSON?heading=Toxicity"},{"id":"r60-2026-09-25-d867-niosh-npg-npgd0565","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Sodium hydroxide (1310-73-2) (reached from the NPG CAS index npgdcas.html, archived 2026-09-25)","url":"https://www.cdc.gov/niosh/npg/npgd0565.html"},{"id":"r60-2026-09-30-d907-f1d6179110","type":"regulatory","title":"Industry Code of Practice on Chemicals Classification and Hazard Communication (DOSH Malaysia)","url":"https://dosh.gov.my/wp-content/uploads/2026/06/ICOP-Chemical-Classification-and-Hazard-Communication-2014.pdf"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:ECHA (CLP Annex VI):skin irritation: skin corr. 1a","unmapped_classification:Australia, as recorded by ToxValDB:skin irritation: skin corrosion - 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category 1a (sco","unmapped_classification:Canada, as recorded by ToxValDB:skin irritation: skin corrosion/irritation - categ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 1 (score: very high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 1 (score: very high)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:DOSH Malaysia (ICOP):eye irritation: eye dam. 1","unmapped_classification:DOSH Malaysia (ICOP):skin irritation: skin corr. 1a","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 6.3a (category 2) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 8.2c (category 1c) (scor","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 8.2b (category 1b) (scor","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: moderate or mild irritati","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: severe irritation (score:","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: severe irritation (score","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: moderate or mild irritat","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: corrosive or irritation p"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","dog","cat","exposure_ingestion","exposure_dermal","exposure_ocular","human_teen","human_elderly","human_infant","human_pregnant","exposure_inhalation","occupational_exposure"]}