{"hq_id":"hq-c-ino-000017","name":"Zinc (metallic/ionic)","context":"human_adult","timestamp":"2026-10-27T17:11:46.726Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000017","sha256":"13e3990e862b153f0a5df6ec698c2e2f6bb82e346e80f07570ec2c514e0516ca"}]},"risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"who_zinc","type":"regulatory","title":"WHO: Zinc — Environmental Health Criteria and Dietary Requirements (Essential Metals in Human Health and Disease)","year":2001},{"id":"epa_zinc_aquatic","type":"regulatory","title":"US EPA: Aquatic Life Ambient Freshwater Quality Criteria — Zinc","year":2016},{"id":"r60-2026-09-25-d449-iris-426","type":"regulatory","title":"Zinc and Compounds | CASRN 7440-66-6 | DTXSID7035012 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=426"},{"id":"r60-2026-10-01-dd54-hc-trvs-v2-h128-1-11-638","type":"regulatory","title":"Federal Contaminated Site Risk Assessment in Canada, Part II: Health Canada Toxicological Reference Values (TRVs) and Chemical-Specific Factors, Version 2.0","url":"http://publications.gc.ca/collections/collection_2012/sc-hc/H128-1-11-638-eng.pdf"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_23994","type":"pubchem","title":"PubChem: Toxicity section (CID 23994)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/23994/JSON?heading=Toxicity"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:EPA CTX / IRIS:inadequate information to assess carcinogenic pote","unmapped_classification:EPA CTX / IRIS:data are inadequate for an assessment of human car","unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / Health Canada:iom does not consider zinc carcinogenic to humans","unmapped_classification:EPA IRIS:group d not classifiable as to human carcinogenici","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2b (score: moderate)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: moderate or mild irritati","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":50,"warnings":["unmapped_classification:EPA CTX / IRIS:inadequate information to assess carcinogenic pote","unmapped_classification:EPA CTX / IRIS:data are inadequate for an assessment of human car","unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / Health Canada:iom does not consider zinc carcinogenic to humans","unmapped_classification:EPA IRIS:group d not classifiable as to human carcinogenici","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2b (score: moderate)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: moderate or mild irritati"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["dog","cat","human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}