{"hq_id":"hq-c-ino-000009","name":"Cobalt","context":"human_adult","timestamp":"2026-08-28T03:00:02.616Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.692048,"weightedMean":0.692048,"std_dev":0.063455,"confidence_interval_95":[0.65,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"IARC","year":2023,"value":0.7,"weight":0.45018},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.740211,"weightedMean":0.740211,"std_dev":0.138442,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2023,"value":0.82,"weight":0.45018},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.583632,"weightedMean":0.583632,"std_dev":0.252195,"confidence_interval_95":[0.549,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2023,"value":0.549,"weight":0.45018},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.925198,"weightedMean":0.925198,"std_dev":0.129789,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2023,"value":1,"weight":0.45018},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.792388,"weightedMean":0.792388,"std_dev":0.073547,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2023,"value":0.75,"weight":0.45018},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.576967,"disagreement_magnitude":0.293369,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_86_cobalt","type":"regulatory","title":"IARC Monographs Volume 86: Cobalt in Hard Metals and Cobalt Sulfate, Gallium Arsenide, Indium Phosphide and Vanadium Pentoxide","year":2006},{"id":"atsdr_cobalt","type":"report","title":"ATSDR Toxicological Profile for Cobalt","year":2004},{"id":"niosh_cobalt","type":"regulatory","title":"NIOSH Hazard Review: Health Effects of Occupational Exposure to Respirable Crystalline Silica — Cobalt","year":2009}],"sources_scope":"context","warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sens. 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: sah (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sensitization - category ","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sens. 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): high frequ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: in vivo: severe irritation (score:"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":40,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sens. 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: sah (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sensitization - category ","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sens. 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): high frequ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: in vivo: severe irritation (score:"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_inhalation","exposure_dermal","human_teen","human_elderly","human_infant","human_pregnant","exposure_ingestion","exposure_ocular","occupational_exposure"]}