{"hq_id":"hq-c-ino-000007","name":"Beryllium","context":"human_adult","timestamp":"2026-10-27T21:22:21.928Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000007","sha256":"73c925ed629773b72e81afbd7e92814a70e01f9e2e5b85f5d916d3403b0fd817"}]},"risk_level":"severe","risk_profile":{"magnitude":{"mean":0.796493,"weightedMean":0.796493,"std_dev":0.12144,"confidence_interval_95":[0.625,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.85,"weight":0.30176},{"source":"US EPA","year":2021,"value":0.75,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.743901,"weightedMean":0.743901,"std_dev":0.136238,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41},{"source":"US EPA","year":2021,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.591841,"weightedMean":0.591841,"std_dev":0.233646,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41},{"source":"US EPA","year":2021,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.928657,"weightedMean":0.928657,"std_dev":0.127723,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41},{"source":"US EPA","year":2021,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.790428,"weightedMean":0.790428,"std_dev":0.072376,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41},{"source":"US EPA","year":2021,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.1904,"disagreement_magnitude":0.339684,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_100c_be","type":"regulatory","title":"IARC Monographs Volume 100C: Beryllium and Beryllium Compounds — Arsenic, Metals, Fibres, and Dusts","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304379/"},{"id":"epa_be_iris","type":"regulatory","title":"US EPA IRIS: Beryllium and Compounds","year":1998,"url":"https://cfpub.epa.gov/ncea/iris2/chemicalLanding.cfm?substance_nmbr=12"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-27-d903-ecfr-29cfr1910.1024","type":"regulatory","title":"§ 1910.1024 Beryllium.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-24/title-29.xml?part=1910&section=1910.1024"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-09-30-d918-iris-landing-12-beryllium-and-compounds","type":"regulatory","title":"Beryllium and compounds | CASRN 7440-41-7 | DTXSID4023913 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=12"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) (secondary: unofficial by its own statement)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"r60-2026-09-26-d867-niosh-npg-npgd0054","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Beryllium & beryllium compounds (as Be) (7440-41-7) (reached from the NPG CAS index npgdcas.html, archived 2026-09-25)","url":"https://www.cdc.gov/niosh/npg/npgd0054.html"},{"id":"r60-2026-09-30-d907-f1d6179110","type":"regulatory","title":"Industry Code of Practice on Chemicals Classification and Hazard Communication (DOSH Malaysia)","url":"https://dosh.gov.my/wp-content/uploads/2026/06/ICOP-Chemical-Classification-and-Hazard-Communication-2014.pdf"},{"id":"r60-2026-09-25-d897-eu-cellar-02004L0037-20240408","type":"regulatory","title":"Consolidated TEXT: 32004L0037 — EN — 08.04.2024","url":"https://publications.europa.eu/resource/celex/02004L0037-20240408"},{"id":"r60-2026-09-27-d820-osha-annotated-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1 | Occupational Safety and Health Administration","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / IRIS:carcinogenic potential cannot be determined","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:ECHA (CLP Annex VI):eye irritation: eye irrit. 2","unmapped_classification:ECHA (CLP Annex VI):skin irritation: skin irrit. 2","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Germany, as recorded by ToxValDB:skin sensitization: sah (score: high)","unmapped_classification:Australia, as recorded by ToxValDB:skin sensitization: skin sensitisation - category ","unmapped_classification:Canada, as recorded by ToxValDB:skin sensitization: skin sensitization - category ","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)","unmapped_classification:DOSH Malaysia (ICOP):eye irritation: eye irrit. 2","unmapped_classification:DOSH Malaysia (ICOP):skin irritation: skin irrit. 2","unmapped_classification:DOSH Malaysia (ICOP):skin sensitization: skin sens. 1","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: studies indicate no sign","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: studies indicate no signi","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":48,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / IRIS:carcinogenic potential cannot be determined","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:ECHA (CLP Annex VI):eye irritation: eye irrit. 2","unmapped_classification:ECHA (CLP Annex VI):skin irritation: skin irrit. 2","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Germany, as recorded by ToxValDB:skin sensitization: sah (score: high)","unmapped_classification:Australia, as recorded by ToxValDB:skin sensitization: skin sensitisation - category ","unmapped_classification:Canada, as recorded by ToxValDB:skin sensitization: skin sensitization - category ","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)","unmapped_classification:DOSH Malaysia (ICOP):eye irritation: eye irrit. 2","unmapped_classification:DOSH Malaysia (ICOP):skin irritation: skin irrit. 2","unmapped_classification:DOSH Malaysia (ICOP):skin sensitization: skin sens. 1","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: studies indicate no sign","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: studies indicate no signi","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_inhalation","human_child","exposure_dermal","exposure_ingestion","dog","cat","human_teen","human_elderly","human_infant","human_pregnant","exposure_ocular","occupational_exposure"]}