{"hq_id":"hq-c-ino-000001","name":"Lead (Pb)","context":"human_adult","timestamp":"2026-06-17T13:16:45.464Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.685841,"weightedMean":0.685841,"std_dev":0.048438,"confidence_interval_95":[0.65,0.75],"source_positions":[{"source":"US EPA","year":2004,"value":0.75,"weight":0.41},{"source":"IARC","year":2006,"value":0.7,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.743901,"weightedMean":0.743901,"std_dev":0.136238,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2006,"value":0.82,"weight":0.41},{"source":"US EPA","year":2004,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.591841,"weightedMean":0.591841,"std_dev":0.233646,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2006,"value":0.5,"weight":0.41},{"source":"US EPA","year":2004,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.928657,"weightedMean":0.928657,"std_dev":0.127723,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2006,"value":1,"weight":0.41},{"source":"US EPA","year":2004,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.790428,"weightedMean":0.790428,"std_dev":0.072376,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2006,"value":0.75,"weight":0.41},{"source":"US EPA","year":2004,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.67708,"disagreement_magnitude":0.308845,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. US EPA classifies as higher risk (75th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":"Bone lead releases endogenously during aging, weight loss, and osteoporosis. Cognitive decline, memory impairment, and mood disorders documented at low levels.","warning":null},"sources":[],"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:EPA CTX / IRIS:b2 (probable human carcinogen - based on sufficien","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: none, 1 positive / 2","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: none, 1 positive / 2","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: studies indicate no sign","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: in vivo: studies indicate no signi","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":44,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:EPA CTX / IRIS:b2 (probable human carcinogen - based on sufficien","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: none, 1 positive / 2","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: none, 1 positive / 2","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: studies indicate no sign","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: in vivo: studies indicate no signi","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer"}